Leaving Alfred out is impossible, imo. Not an option. They'd be ignoring a huge part of what makes Batman Batman. That's like taking Lois Lane out of a Superman film.
It's not that much different than leaving out Robin in my view. He too is a huge part of what makes Batman Batman. Definitely not impossible. I don't think Lois Lane is comparable.
I would prefer it if they leave Alfred for a sequel perhaps. But if they must include the character in this one, maybe have him be at odds with Wayne. Have him be a new addition to Wayne Manor while Bruce insists he has no use for him. Let Alfred be ignorant of the Batman's true identity and a thorn in Bruce's side, at least until the end of the film. Something like that would go a long way in making the character work for this version.